Co-administration of Shexiang Baoxin Pill and Chemotherapy Drugs Potentiated Cancer Therapy by Vascular-Promoting Strategy
Identifieur interne : 000947 ( Main/Exploration ); précédent : 000946; suivant : 000948Co-administration of Shexiang Baoxin Pill and Chemotherapy Drugs Potentiated Cancer Therapy by Vascular-Promoting Strategy
Auteurs : Liu-Qing Yang [République populaire de Chine] ; Ru-Yi Li [République populaire de Chine] ; Xi-Yan Yang [République populaire de Chine] ; Qian-Fei Cui [République populaire de Chine] ; Fei-Yun Wang [République populaire de Chine] ; Guo-Qiang Lin [République populaire de Chine] ; Jian-Ge Zhang [République populaire de Chine]Source :
- Frontiers in Pharmacology [ 1663-9812 ] ; 2019.
Abstract
Effective delivery of chemotherapeutic agents to tumors is a critical objective of improved cancer therapy. Traditional antiangiogenic therapy aims at eradicating tumor blood vessels, but the subsequently reduced blood perfusion may limit the drug amount delivered into the tumor and potentially lead to tumor hypoxia, which has been proved to be unable to meet the therapeutic expectations. “Shexiang Baoxin Pill” (SBP) is a well-known traditional Chinese medicine (TCM) used in clinical treatment of cardiovascular diseases, which has the pharmacological effect of pro-angiogenesis demonstrated recently. In this study, we disclosed our finding that SBP could enhance the effective treatment performance of gemcitabine (GEM) while minimizing the toxic side effects caused by GEM. Mechanistically, SBP increased tumor angiogenesis, blood perfusion, vascular permeability, and vessel dilation, which subsequently favored the delivery of GEM to the tumor lesion. Moreover, combined treatment with SBP and GEM could modify tumor microenvironment and consequently overcome multidrug resistance, and this combination therapy is also suitable for combination of SBP with some other chemotherapeutic drugs as well. These results suggest that combining SBP with chemotherapeutic agents achieves better treatment efficiency, which can open an avenue for expanding the combined treatment of anti-cancer chemotherapeutic drugs with TCM.
Url:
DOI: 10.3389/fphar.2019.00565
PubMed: 31178734
PubMed Central: 6543272
Affiliations:
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see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Li, Ru Yi" sort="Li, Ru Yi" uniqKey="Li R" first="Ru-Yi" last="Li">Ru-Yi Li</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Department of Respiratory and Critical Care Medicine, National Key Clinical Specialty, Xiangya Hospital, Central South University</institution>,<addr-line>Changsha</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Yang, Xi Yan" sort="Yang, Xi Yan" uniqKey="Yang X" first="Xi-Yan" last="Yang">Xi-Yan Yang</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>School of Pharmaceutical Sciences, Zhengzhou University</institution>,<addr-line>Zhengzhou</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see 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nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lin, Guo Qiang" sort="Lin, Guo Qiang" uniqKey="Lin G" first="Guo-Qiang" last="Lin">Guo-Qiang Lin</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine</institution>,<addr-line>Shanghai</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhang, Jian Ge" sort="Zhang, Jian Ge" uniqKey="Zhang J" first="Jian-Ge" last="Zhang">Jian-Ge Zhang</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine</institution>,<addr-line>Shanghai</addr-line>,<country>China</country></nlm:aff><country 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id="aff2"><institution>School of Pharmaceutical Sciences, Zhengzhou University</institution>,<addr-line>Zhengzhou</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Li, Ru Yi" sort="Li, Ru Yi" uniqKey="Li R" first="Ru-Yi" last="Li">Ru-Yi Li</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Department of Respiratory and Critical Care Medicine, National Key Clinical Specialty, Xiangya Hospital, Central South University</institution>,<addr-line>Changsha</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Yang, Xi Yan" sort="Yang, Xi Yan" uniqKey="Yang X" first="Xi-Yan" last="Yang">Xi-Yan Yang</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>School of Pharmaceutical Sciences, Zhengzhou University</institution>,<addr-line>Zhengzhou</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cui, Qian Fei" sort="Cui, Qian Fei" uniqKey="Cui Q" first="Qian-Fei" last="Cui">Qian-Fei Cui</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>School of Pharmaceutical Sciences, Zhengzhou University</institution>,<addr-line>Zhengzhou</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Fei Yun" sort="Wang, Fei Yun" uniqKey="Wang F" first="Fei-Yun" last="Wang">Fei-Yun Wang</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine</institution>,<addr-line>Shanghai</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lin, Guo Qiang" sort="Lin, Guo Qiang" uniqKey="Lin G" first="Guo-Qiang" last="Lin">Guo-Qiang Lin</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine</institution>,<addr-line>Shanghai</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhang, Jian Ge" sort="Zhang, Jian Ge" uniqKey="Zhang J" first="Jian-Ge" last="Zhang">Jian-Ge Zhang</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine</institution>,<addr-line>Shanghai</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Frontiers in Pharmacology</title><idno type="eISSN">1663-9812</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Effective delivery of chemotherapeutic agents to tumors is a critical objective of improved cancer therapy. Traditional antiangiogenic therapy aims at eradicating tumor blood vessels, but the subsequently reduced blood perfusion may limit the drug amount delivered into the tumor and potentially lead to tumor hypoxia, which has been proved to be unable to meet the therapeutic expectations. “Shexiang Baoxin Pill” (SBP) is a well-known traditional Chinese medicine (TCM) used in clinical treatment of cardiovascular diseases, which has the pharmacological effect of pro-angiogenesis demonstrated recently. In this study, we disclosed our finding that SBP could enhance the effective treatment performance of gemcitabine (GEM) while minimizing the toxic side effects caused by GEM. Mechanistically, SBP increased tumor angiogenesis, blood perfusion, vascular permeability, and vessel dilation, which subsequently favored the delivery of GEM to the tumor lesion. Moreover, combined treatment with SBP and GEM could modify tumor microenvironment and consequently overcome multidrug resistance, and this combination therapy is also suitable for combination of SBP with some other chemotherapeutic drugs as well. These results suggest that combining SBP with chemotherapeutic agents achieves better treatment efficiency, which can open an avenue for expanding the combined treatment of anti-cancer chemotherapeutic drugs with TCM.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Abi Aad, S" uniqKey="Abi Aad S">S. Abi Aad</name></author><author><name sortKey="Pierce, M" uniqKey="Pierce M">M. Pierce</name></author><author><name sortKey="Barmaimon, G" uniqKey="Barmaimon G">G. Barmaimon</name></author><author><name sortKey="Farhat, F S" uniqKey="Farhat F">F. S. Farhat</name></author><author><name sortKey="Benjo, A" uniqKey="Benjo A">A. 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Chang</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Yang, Liu Qing" sort="Yang, Liu Qing" uniqKey="Yang L" first="Liu-Qing" last="Yang">Liu-Qing Yang</name></noRegion><name sortKey="Cui, Qian Fei" sort="Cui, Qian Fei" uniqKey="Cui Q" first="Qian-Fei" last="Cui">Qian-Fei Cui</name><name sortKey="Li, Ru Yi" sort="Li, Ru Yi" uniqKey="Li R" first="Ru-Yi" last="Li">Ru-Yi Li</name><name sortKey="Lin, Guo Qiang" sort="Lin, Guo Qiang" uniqKey="Lin G" first="Guo-Qiang" last="Lin">Guo-Qiang Lin</name><name sortKey="Wang, Fei Yun" sort="Wang, Fei Yun" uniqKey="Wang F" first="Fei-Yun" last="Wang">Fei-Yun Wang</name><name sortKey="Yang, Liu Qing" sort="Yang, Liu Qing" uniqKey="Yang L" first="Liu-Qing" last="Yang">Liu-Qing Yang</name><name sortKey="Yang, Xi Yan" sort="Yang, Xi Yan" uniqKey="Yang X" first="Xi-Yan" last="Yang">Xi-Yan Yang</name><name sortKey="Zhang, Jian Ge" sort="Zhang, Jian Ge" uniqKey="Zhang J" first="Jian-Ge" last="Zhang">Jian-Ge Zhang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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